Hep C is a killer. 95% of cases lead to chronic liver problems. We are beginning to understand its mode of replication..
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Hepatitis C kills more people each year than HIV and 59 other diseases. Many remain unaware of hepatitis C and the majority living with this chronic liver disease do not have symptoms. The Johns Hopkins Viral Hepatitis Center’s clinical team located in the John G. Bartlett Specialty Practice in Baltimore welcomes you to walk-in to clinic for a free, rapid hepatitis C screening test and efficient linkage to hepatitis C care. We have case managers, nurses, viral hepatitis clinical experts and pharmacists to help more people get tested, treated and cured of this life-threatening disease.
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Hepatitis C Virus is a common cause of Liver SCARRING ~ Cirrhosis. It is the the most common reason for Liver Transplant is the US. This dangerous disease that can be PREVENTED & TREATED. Learn how Hepatitis C affects our body? How Hep C virus enters our body and how does it spread to others? How can Hep C be prevented? What is Cirrhosis? and how is Hep C treated? Ask Dr. SMART!
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Hepatitis C, often abbreviated HCV, is a DNA virus that is most often transmitted by the sharing of infected needles. It can often lead to serious liver conditions if left untreated. Join Dr. Dominic Rowley as he explains the virus in detail.
See below for an overview of points covered in this video.
For more information please navigate to:
https://www.letsgetchecked.com/sti-testing/?utm_source=youtube&utm_medium=video&utm_campaign=Rowley_Videos_YT&utm_term=Hepatitis%20C&utm_content=video%20description
0:10 – What is hepatitis C?
0:30 – How is hepatitis C transmitted?
1:26 – Hepatitis C, symptoms and complications?
2:11 – What is the test for hepatitis B?
2:50 – How to get tested?
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Have you ever thought about the effects Hepatitis C (HCV) may have on individuals? Did you ever think about whether or not the disease can be fatal? Be sure to watch this video to make sure you find out the molecular mechanisms of the disease, symptoms, and methods of transmission in place. This video will give you insight of statistics in Canada as well as globally on cure rate, survival rate, and death rates of HCV.
Kindly click the following link for the video transcript with timestamps:
https://docs.google.com/document/d/12PP-CMdLAqx-wrPyAS-_xfFUS7dvye2T293T2RM9Aao/e dit?usp=sharing
This video was made by McMaster Demystifying Medicine students: Abdel-Rahman Mohamed-El Faki, Maiura Muralitharan, and Mansi Patel in collaboration with the McMaster Demystifying Medicine Program.
Copyright McMaster University 2020
References:
1. Canada, P. (2018, June 07). Government of Canada. Retrieved November 08, 2020, from
https://www.canada.ca/en/public-health/services/reports-publications/canada-communic able-disease-report-ccdr/monthly-issue/2018-44/issue-7-8-july-5-2018/article-7-hepatitis- c-canada-2018-infographic.html
2. Canada, P. (2020, August 14). Government of Canada. Retrieved November 08, 2020, from https://www.canada.ca/en/public-health/services/diseases/hepatitis-c.html
3. Commissioner, O. (n.d.). Hepatitis C Treatments Give Patients More Options. Retrieved November 08, 2020, from https://www.fda.gov/consumers/consumer-updates/hepatitis-c-treatments-give-patients- more-options
4. Carrat, F., Fontaine, H., Dorival, C., Simony, M., Diallo, A., Hezode, C., … & Zoulim, F. (2019). Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study. The Lancet, 393(10179), 1453-1464. doi: https://doi.org/10.1016/S0140-6736(18)32111-1
5. Gale, M., Blakely, C. M., Kwieciszewski, B., Tan, S. L., Dossett, M., Tang, N. M., … & Katze, M. G. (1998). Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Molecular and cellular biology,
18( 9), 5208-5218. doi: 10.1128/MCB.18.9.5208
6. Ghany, M. G., Marks, K. M., Morgan, T. R., Wyles, D. L., Aronsohn, A. I., Bhattacharya, D., … & Heller, T. (2019). Hepatitis C guidance 2019 update: AASLD-IDSA recommendations for testing, managing, and treating hepatitis C virus infection. Hepatology, 71(2), 686-721. doi: 10.1002/hep.31060
7. Hepatitis C Symptoms. Diagnosing Hepatitis C – ALF. (2020, March 10). Retrieved
November 08, 2020, from https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/hepatitis-c/dia gnosing-hepatitis-c/
8. Hepatitis C Treatment. Treatment for Hepatitis C Info – ALF. (2020, April 13). Retrieved November 08, 2020, from https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/hepatitis-c/trea ting-hepatitis-c/
9. National Progress Report 2025 Goal: Reduce reported rate of hepatitis C-related deaths by ≥20%. (2020, August 11). Retrieved November 08, 2020, from https://www.cdc.gov/hepatitis/policy/NationalProgressReport-HepC-ReduceDeaths.htm
10. Khatun, M., & Ray, R. B. (2019). Mechanisms underlying hepatitis C Virus-associated hepatic fibrosis. Cells, 8( 10), 1249. doi: https://doi.org/10.3390/cells8101249
11. Owens, D. K., Davidson, K. W., Krist, A. H., Barry, M. J., Cabana, M., Caughey, A. B., … & Ogedegbe, G. (2020). Screening for hepatitis C virus infection in adolescents and adults: US Preventive Services Task Force recommendation statement. Jama, 323(10), 970-975. doi: 10.1001/jama.2020.1123
12. Schillie, S., Wester, C., Osborne, M., Wesolowski, L., & Ryerson, A. B. (2020). CDC recommendations for hepatitis C screening among adults—United States, 2020. MMWR Recommendations and Reports, 69( 2), 1. doi: 10.15585/mmwr.rr6902a1
13. van de Laar, T. J., van der Bij, A. K., Prins, M., Bruisten, S. M., Brinkman, K., Ruys, T. A., … & Jurriaans, S. (2007). Increase in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission. The Journal of infectious diseases, 196( 2), 230-238. doi: https://doi.org/10.1086/518796
14. Vescovo, T., Refolo, G., Vitagliano, G., Fimia, G. M., & Piacentini, M. (2016). Molecular mechanisms of hepatitis C virus–induced hepatocellular carcinoma. Clinical Microbiology and Infection, 22( 10), 853-861. doi: https://doi.org/10.1016/j.cmi.2016.07.019
15. Zeisel, M. B., Fofana, I., Fafi-Kremer, S., & Baumert, T. F. (2011). Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies. Journal of hepatology, 54(3), 566-576. doi: https://doi.org/10.1016/j.jhep.2010.10.014
Credits:
The HCV life cycle animations were adapted from
UCLA-Mellinkoff Gastroenterology and Hepatology Symposium
March 6-7, 2020
Learn more about the UCLA Vatche & Taman Manoukian Division of Digestive Disease at www.uclahealth.org/gastro
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Hepatitis C is a viral infection causing liver disease. Over 3 million people in the US are infected with hepatitis C and over half remain undiagnosed. The vast majority of individuals living with hepatitis C do not have symptoms. Hepatitis C is transmitted through contact with infected blood and many are unaware of their infection. If left untreated, hepatitis C can damage the liver to the point of cirrhosis, liver cancer and liver failure. The good news is that there are short-duration treatments that can lead to cure. The Johns Hopkins Viral Hepatitis Center is here to help more people get tested, treated and cured of this life-threatening disease. Learn more at: https://www.hopkinsmedicine.org/infectious-diseases/Patient_Care/outpatient/ViralHepatitis.html
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